The relationship between variable region determinants and antigen specificity on mitogen reactive B cell subsets

Determinants on T Cell Factors Coded

Thymus-derived(T) lymphocytes have been shown to display antigen specificity. The antigen-recognition units on T lymphocytes, in contrast to those on B lymphocytes, do not appear to be of the conventional immunoglobul in (Ig) type. Recent studies from various laboratories (1-5) have demonstrated that the antigen-specific T cell factors derived from helper or suppressor T cells possess the ant i...

The Immunomodulatory Effect of Cyclophosphamide on Regulation of T-Cell Subsets and Antigen Presenting Cells.

The Significance of B-cell Subsets in Patients with Unclassified Hypogammaglobulinemia and Association with Intravenous Immunoglobulin Replacement Requirement

Background: Patients with unclassified hypogammaglobulinemia (UCH) constitute a diagnostic and therapeutic dilemma, because information concerning the clinical and immunological characteristics of these patients is insufficient. Objective: To evaluate B-cell subsets in cases with UCH and common variable immunodeficiency (CVID) and their association with treatment requirement in UCH patients. Me...

Antigen- and receptor-driven regulatory mechanisms. IV. Idiotype- bearing I-J+ suppressor T cell factors induce second-order suppressor T cells which express anti-idiotypic receptors

Administration of azobenzenearsonate (ABA)-coupled syngeneic spleen cells intravenously to A/J mice leads to the generation of suppressor T cells (Ts1) which exhibit specific binding to ABA-bovine serum albumin (BSA)-coated dishes. These Ts1 share idiotypic determinants with the major cross-reactive idiotype (CRI) of the anti-ABA antibodies of A/J mice, and also produce a soluble suppressor fac...

Idiotypic analysis of lymphocytes in vitro. I. Specificity and heterogeneity of B and T lymphocytes reactive with anti-idiotypic antibody

Guinea pig anti-idiotypic antibodies (anti-Id) of the IgG1 class, directed to an A/J antibody to Group A streptococcal carbohydrate (A-CHO), or directed to a BALB/c myeloma protein that binds the same antigen, stimulate B-precursor cells as well as T-helper cells when injected into mice of the appropriate strain. The strain-specific induction of both precursor and helper activity was detected b...